How often must most IACUC-approved protocols undergo a formal review, and what does this review assess?

• A. Annually; ongoing welfare, adherence to the protocol, and any changes in usage or endpoints.
• B. Biannually; budget and personnel changes only.
• C. Quarterly; data collection methods.
• D. Once at approval and never again.

Answer: (A)

Regular continuing review is a fundamental part of IACUC oversight. Most IACUC-approved protocols undergo a formal review each year to verify that animals are being cared for and used according to the approved plan, and to catch any changes that could affect welfare or scientific validity. This annual check specifically assesses ongoing welfare and housing, ensures procedures are still performed as approved, and evaluates any changes in how animals are used or what endpoints or humane endpoints are defined. If issues arise—such as unexpected adverse effects, refinements needed, or updated endpoints—the committee can require modifications or amendments. Administrative changes like budget or staffing are not the primary focus of the ongoing review, and a one-time approval with no regular follow-up would not meet standard oversight practice.