Name two core responsibilities of the IACUC after protocol approval.

• A. Review grant proposals
• B. Conduct ongoing oversight of approved protocols and semiannual inspections of facilities and care
• C. Issue licenses for animal housing
• D. Manage animal procurement records only

Answer: (B)

After a protocol is approved, the IACUC's role shifts to making sure that approved work stays within the agreed-upon humane and regulatory standards. The two main post-approval responsibilities are ongoing oversight of approved protocols and semiannual inspections of facilities and care.

Ongoing oversight means the committee continually monitors the protocol's implementation, reviews any changes or amendments before they’re enacted, and follows up on adverse events, deviations, or deviations from the approved procedures. It also covers ensuring appropriate veterinary care, proper training of personnel, and that records reflect current practices and compliance.

Semiannual inspections involve visiting all animal housing and care areas to assess the conditions, husbandry, enrichment, sanitation, and overall welfare of the animals, as well as verifying that records and practices align with the approved protocol. Any issues found lead to corrective actions and, if needed, protocol amendments or renewals.

These duties focus on post-approval governance, and they aren’t about grant reviews or licensing or solely procurement records, which are outside the IACUC’s post-approval scope.