What determines the frequency of continuing IACUC protocol reviews?

• A. It can vary by policy and protocol type.
• B. It is the same for all protocols.
• C. It occurs only at protocol renewal.
• D. It is determined by the lead investigator.

Answer: (A)

Review frequency is set by the institution’s IACUC policy and by the characteristics of the protocol. Federal requirements require continuing review of approved protocols, typically at least once a year, but institutions can adopt shorter or longer intervals depending on factors such as the level of risk, the procedures involved, species used, and any changes to the protocol. The lead investigator doesn’t decide the interval; the IACUC uses its policy and the protocol type to determine how often continuing review occurs. This ensures ongoing animal welfare and compliance with approved procedures, and allows adjustments if new information or concerns arise.