What is the relationship between the Guide and the IACUC?

• A. The Guide is optional and not used by IACUC.
• B. The IACUC creates its own standards independent of the Guide.
• C. The Guide and IACUC operate in parallel but unrelated.
• D. The IACUC uses the Guide as the standard for evaluating animal care and use; adherence to the Guide is expected for compliance with PHS Policy.

Answer: (D)

The Guide provides the standard used by the IACUC to evaluate animal care and use. It lays out minimum requirements for housing, husbandry, veterinary care, procedures, and welfare, and the IACUC uses those standards when reviewing protocols, inspecting facilities, and monitoring ongoing activities. Adherence to the Guide is expected for compliance with the Public Health Service Policy on Humane Care and Use of Laboratory Animals, so institutions must follow the Guide to meet PHS requirements. In short, the IACUC relies on the Guide as the benchmark for evaluating care and use, and compliance with the Guide supports overall regulatory compliance.