Who supervises procedures under approved protocols?

• A. Personnel listed on the protocol who have completed required training, under supervision of the PI and IACUC.
• B. Only the PI can supervise.
• C. The IO supervises all procedures.
• D. IACUC alone supervises.

Answer: (A)

Supervision of procedures under approved protocols relies on qualified, listed personnel being overseen by the PI with IACUC oversight. Only those staff members who are named on the protocol and have completed the required training may carry out procedures, and they do so under the direction of the Principal Investigator and the IACUC. The PI is responsible for day-to-day conduct and ensuring proper training and compliance, while the IACUC provides ongoing oversight and protocol-level monitoring. The Institutional Official does not directly supervise routine procedures, and the IACUC alone does not manage every daily activity. This combined arrangement—trained staff listed on the protocol supervised by the PI with IACUC oversight—best aligns with how approved protocols are managed.